Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

Simple Summary The uPA/uPAR system is highly involved in cancer progression and
metastasis. Many studies have definitively assessed that the high expression of urokinase …

Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type
plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is …

Proteolysis is a key event in several biological processes; proteolysis must be tightly
controlled because its improper activation leads to dramatic consequences. Deregulation of …

Abstract Background BRAF inhibitor (BRAF-I) therapy for melanoma patients harboring the
V600E mutation is initially highly effective, but almost all patients relapse within a few …

The high expression of uPAR has been linked to tumor progression, invasion, and
metastasis in several types of cancer. Such overexpression of uPAR makes it a potential …

Многофункциональная система активатора плазминогена урокиназного типа (uPA-
система) включает сериновую протеиназу—uPA или урокиназу, ее рецептор—uPAR и …

The degradation of the extracellular matrix plays an important role in the processes of
morphogenesis, angio-and neurogenesis, wound healing, inflammation, carcinogenesis …

The multifunctional urokinase-type plasminogen activator system (uPA-system) includes
serine proteinase—uPA or urokinase, its receptor (uPAR) and two inhibitors (PAI-1 and PAI …

Background Chronic obstructive pulmonary disease (COPD) is a major health problem
associated with high mortality worldwide. Cigarette smoke (CS) exposure is the main cause …