The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Fungal infections are an increasing threat to global public health. There are more than six
million fungal species worldwide, but less than 1% are known to infect humans. Most of …

African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …

Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but
mechanisms of vaccine-elicited pathogen clearance remain largely undefined. We report …

Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue
macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic of severe coronavirus disease 2019 (COVID-19). Staphylococcus aureus is …

Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide
range of mammalian hosts, with Trypanosoma evansi having the widest geographic …

Vitamin D deficiency remains a global concern. This 'sunshine'vitamin is converted through
a multistep process to active 1, 25-dihydroxyvitamin D3 (1, 25D), the final step of which can …

The liver is a vital metabolic organ that also performs important immune-regulatory functions.
In the context of infections, the liver represents a target site for various pathogens, while also …

Trypanosomes are known to activate the complement system on their surface, but they
control the cascade in a manner such that the cascade does not progress into the terminal …