Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

The aim of this narrative review is to provide current evidence for the interaction between
obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone …

Stress, that is, the state of threatened or perceived as threatened homeostasis, is associated
with activation of the stress system, mainly comprised by the hypothalamic-pituitary-adrenal …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …

Peripheral mechanisms in appetite regulation include the motor functions of the stomach,
such as the rate of emptying and accommodation, which convey symptoms of satiation to the …

Leptin is secreted by adipose tissue and regulates energy homeostasis, glucose and lipid
metabolism, immune function, and other systems. The binding of leptin to its specific …