Obstructive sleep apnea: current perspectives

AM Osman, SG Carter, JC Carberry… - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Evaluation and management of adults with obstructive sleep apnea syndrome

JJ Lee, KM Sundar - Lung, 2021 - Springer
Obstructive sleep apnea syndrome (OSAS) is a common and underdiagnosed medical
condition characterized by recurrent sleep-dependent pauses and reductions in airflow …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Personalized management approach for OSA

JC Carberry, J Amatoury, DJ Eckert - Chest, 2018 - Elsevier
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea

SA Sands, BA Edwards, PI Terrill… - American journal of …, 2018 - atsjournals.org
Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis
of a patient's own phenotypic causes (“traits”) if a clinically applicable approach were …

Endotypes and phenotypes in obstructive sleep apnea

A Malhotra, O Mesarwi, JL Pepin… - Current opinion in …, 2020 - journals.lww.com
OSA is a heterogeneous disease with highly varying underlying mechanisms. OSA has
variable clinical manifestations with definable subsets having risk of particular …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Quantifying the arousal threshold using polysomnography in obstructive sleep apnea

SA Sands, PI Terrill, BA Edwards… - Sleep, 2018 - academic.oup.com
Abstract Study Objectives Precision medicine for obstructive sleep apnea (OSA) requires
noninvasive estimates of each patient's pathophysiological “traits.” Here, we provide the first …

Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: a systematic review and meta-analysis

PJ Hartfield, J Janczy, A Sharma, HA Newsome… - Sleep Medicine …, 2023 - Elsevier
Upper airway (UA) collapsibility is one of the key factors that determine the severity of
obstructive sleep apnea (OSA). Interventions for OSA are aimed at reducing UA …