Structural studies of RNase P
A Mondragón - Annual review of biophysics, 2013 - annualreviews.org
Ribonuclease P (RNase P) is one of the first ribozymes discovered and it is found in all
phylogenetic groups. It is responsible for processing the 5′ end of pre-tRNAs as well as …
phylogenetic groups. It is responsible for processing the 5′ end of pre-tRNAs as well as …
PPR proteins shed a new light on RNase P biology
A fast growing number of studies identify pentatricopeptide repeat (PPR) proteins as major
players in gene expression processes. Among them, a subset of PPR proteins called …
players in gene expression processes. Among them, a subset of PPR proteins called …
Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P
Binding of precursor tRNAs (ptRNAs) by bacterial ribonuclease P (RNase P) involves an
encounter complex (ES) that isomerizes to a catalytic conformation (ES*). However, the …
encounter complex (ES) that isomerizes to a catalytic conformation (ES*). However, the …
TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells
M Xu, D Senanayaka, R Zhao, T Chigumira… - Nature …, 2024 - nature.com
The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed
DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that …
DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that …
The discovery of a catalytic RNA within RNase P and its legacy
Sidney Altman's discovery of the processing of one RNA by another RNA that acts like an
enzyme was revolutionary in biology and the basis for his sharing the 1989 Nobel Prize in …
enzyme was revolutionary in biology and the basis for his sharing the 1989 Nobel Prize in …
Inner-sphere coordination of divalent metal ion with nucleobase in catalytic RNA
Identification of the function of metal ions and the RNA moieties, particularly nucleobases,
that bind metal ions is important in RNA catalysis. Here we combine single-atom and abasic …
that bind metal ions is important in RNA catalysis. Here we combine single-atom and abasic …
A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor
EA Madrigal-Carrillo, CA Díaz-Tufinio… - Nucleic Acids …, 2019 - academic.oup.com
Ribonucleoprotein (RNP) complexes and RNA-processing enzymes are attractive targets for
antibiotic development owing to their central roles in microbial physiology. For many of these …
antibiotic development owing to their central roles in microbial physiology. For many of these …
The contribution of the C5 protein subunit of Escherichia coli ribonuclease P to specificity for precursor tRNA is modulated by proximal 5′ leader sequences
Recognition of RNA by RNA processing enzymes and RNA binding proteins often involves
cooperation between multiple subunits. However, the interdependent contributions of RNA …
cooperation between multiple subunits. However, the interdependent contributions of RNA …
Dissecting monomer-dimer equilibrium of an RNase P protein provides insight into the synergistic flexibility of 5'leader pre-tRNA recognition
Ribonuclease P (RNase P) is a universal RNA-protein endonuclease that catalyzes
5'precursor-tRNA (ptRNA) processing. The RNase P RNA plays the catalytic role in ptRNA …
5'precursor-tRNA (ptRNA) processing. The RNase P RNA plays the catalytic role in ptRNA …
The RNase P ribozyme
M Gößringer, I Schencking, RK Hartmann - Ribozymes, 2021 - Wiley Online Library
This chapter focuses on the state of knowledge on the structure and function of bacterial
RNase P, efforts to develop antibiotics against bacterial RNase P, and concepts to utilize …
RNase P, efforts to develop antibiotics against bacterial RNase P, and concepts to utilize …