Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

The goal of this review is to summarize studies in which concentrations of circulating
endocannabinoids in humans have been examined in relationship to physiological …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Epidemiological, clinical, and mechanistic preclinical studies conducted in the field of
cardiovascular medicine have led to remarkable progress in our understanding of …

The human gut is densely populated by commensal and symbiotic microbes (the “gut
microbiota”), with the majority of the constituent microorganisms being bacteria …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Obesity is characterised by altered gut microbiota, low‐grade inflammation and increased
endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

The endocannabinoid system is known to have positive effects on depression partly through
its actions on neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF). As BDNF is …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …