Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides,
predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from …

Locked nucleic acids (LNAs) containing one or more 2 '-O, 4 '-C-methylene-linked bicyclic
ribonucleoside monomers possess a number of the prerequisites of an effective antisense …

We use spectroscopic and calorimetric techniques to characterize the binding of the
aminoglycoside antibiotics neomycin, paromomycin, and ribostamycin to a RNA …

We have determined single crystal structures of an A‐DNA decamer and a B‐DNA
dodecamer at 0.83 and 0.95 Å, respectively. The resolution of the former is the highest …

The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid
and its properties as a substrate for the RNase H, as well as to point the crucial structural …

We have used two-dimensional 1H NMR spectroscopy at 750 MHz to determine a high-
resolution solution structure of an oligonucleotide containing restricted nucleotides with a 2 ' …

When used in nucleic acid duplexes, locked nucleic acid (LNA) and 2′-O-methyl RNA
residues enhance the duplex stabilities, and this makes it possible to create much better …

Studies on hydration are important for better understanding of structure and function of
nucleic acids. We compared the hydration of self‐complementary DNA, RNA and 2′‐O …

Site‐directed spin labeling of RNA based on click chemistry is used in combination with
pulsed electron‐electron double resonance (PELDOR) to benchmark a nitroxide spin label …