Exploring and developing multifunctional intelligent biomaterials is crucial to improve next-
generation therapies in tissue engineering and regenerative medicine. Recent findings …

Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …

The interaction of neural progenitor cells (NPCs) with the extracellular matrix (ECM) plays an
important role in neural tissue regeneration. Understanding which motifs of the ECM …

In vivo reprogramming of glia into functional neurons emerges as potential regeneration-
based therapeutics for neural injuries or neurological diseases. Recent studies show that …

Translating successful preclinical research in neurodegenerative diseases into clinical
practice has been difficult. The preclinical disease models used for testing new drugs not …

Parkinson's disease is mainly caused by specific degeneration of dopaminergic neurons
(DA neurons) in the substantia nigra of the middle brain. Over the past two decades …

Brain injury poses a heavy disease burden in the world, resulting in chronic deficits.
Therapies for brain injuries have been focused on pharmacologic, small molecule …

Glial progenitor cells are widely distributed in brain parenchyma and represent a suitable
target for future therapeutic interventions that generate new neurons via in situ …

A reliable disease model is critical to the study of specific disease mechanisms as well as for
the discovery and development of new drugs. Despite providing crucial insights into the …

Regenerative medicine based on transplants obtained from donors or foetal and new-born
mesenchymal stem cells, encounter important obstacles such as limited availability of …