Systemic mastocytosis (SM) has greatly benefited from the broad application of precision
medicine techniques to hematolymphoid neoplasms. Sensitive detection of the recurrent KIT …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

Mast cell activation syndromes (MCASs) are defined by systemic severe and recurrent mast
cell activation, usually in form of anaphylaxis, a substantial, event-related increase of the …

Avapritinib, a highly selective inhibitor of KIT D816V, was approved by the Food and Drug
Administration in 2021 for treatment of advanced systemic mastocytosis (AdvSM) and by the …

Tissue-resident innate immune cells exert a wide range of functions in both adult
homeostasis and pathology. Our understanding of when and how these cellular networks …

Under physiological conditions, skin mast cells play an important role as guardians that
quickly react to stimuli that disturb homeostasis. These cells efficiently support, fight …

Hematopoiesis, or the process of blood cell production, is a paradigm of multi‐lineage
cellular differentiation that has been extensively studied, yet in many aspects remains …

Advanced systemic mastocytosis (AdvSM) is characterized by the presence of KIT D816V
and other somatic mutations (eg, in SRSF2, ASXL1, and RUNX1) in 95% and 60% to 70% of …

Mastocytosis is a rare and complex disease characterized by expansion of clonal mast cells
(MC) in skin and/or various internal organ systems. Involvement of internal organs leads to …

Abstract The KIT D816V mutation is found in> 80% of patients with systemic mastocytosis
(SM) and is key to neoplastic mast cell (MC) expansion and accumulation in affected organs …