Disorders of the enteric nervous system—a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …
and closely resembles components and functions of the central nervous system. Although …
Enteric nervous system development: what could possibly go wrong?
M Rao, MD Gershon - Nature Reviews Neuroscience, 2018 - nature.com
The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …
nervous system (ENS)—which detects and responds to diverse signals from the …
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
MJ Workman, MM Mahe, S Trisno, HM Poling… - Nature medicine, 2017 - nature.com
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …
functions, including motility and epithelial permeability. Perturbations in ENS development …
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing
K Morarach, A Mikhailova, V Knoflach, F Memic… - Nature …, 2021 - nature.com
Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …
hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease
The enteric nervous system (ENS) is derived from both the vagal and sacral component of
the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human …
the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human …
Dedicated macrophages organize and maintain the enteric nervous system
Correct development and maturation of the enteric nervous system (ENS) is critical for
survival. At birth, the ENS is immature and requires considerable refinement to exert its …
survival. At birth, the ENS is immature and requires considerable refinement to exert its …
[HTML][HTML] scRNA-Seq reveals new enteric nervous system roles for GDNF, NRTN, and TBX3
CM Wright, S Schneider, KM Smith-Edwards… - Cellular and molecular …, 2021 - Elsevier
Background and Aims Bowel function requires coordinated activity of diverse enteric neuron
subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate …
subtypes. Our aim was to define gene expression in these neuron subtypes to facilitate …
[HTML][HTML] Development of the intrinsic and extrinsic innervation of the gut
T Uesaka, HM Young, V Pachnis, H Enomoto - Developmental biology, 2016 - Elsevier
The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …
Lineage-dependent spatial and functional organization of the mammalian enteric nervous system
The enteric nervous system (ENS) is essential for digestive function and gut homeostasis.
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …
Building a second brain in the bowel
M Avetisyan, EM Schill… - The Journal of clinical …, 2015 - Am Soc Clin Investig
The enteric nervous system (ENS) is sometimes called the “second brain” because of the
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …