Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

Human lungs enable efficient gas exchange and form an interface with the environment,
which depends on mucosal immunity for protection against infectious agents. Tightly …

The atopic march refers to the natural history of allergic diseases as they develop during
infancy and childhood. Introduced by the American allergists AF Coca and RA Cooke in …

Background Thymic stromal lymphopoietin (TSLP) is an epithelial-cell–derived cytokine that
may be important in initiating allergic inflammation. AMG 157 is a human anti-TSLP …

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

The discovery of IgE represented a major breakthrough in allergy and asthma research,
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …