Since the discovery of the Escherichia coli leucine-responsive regulatory protein (Lrp)
almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of …

Metabolic engineering seeks to rewire the metabolic network of cells for the efficient
production of value-added compounds from renewable substrates. However, it remains …

Lincomycin is a broad-spectrum antibiotic and particularly effective against Gram-positive
pathogens. Albeit familiar with the biosynthetic mechanism of lincomycin, we know less …

Methyl parathion is an organophosphorus pesticide widely employed worldwide to control
pests in agricultural and domestic environments. However, due to its intensive use, high …

Streptomyces scabies is the best‐characterized plant‐pathogenic streptomycete, which is a
special species among the large genus Streptomyces. The pathogenicity of S. scabies relies …

Abstract The Actinomycetes Streptomyces lincolnensis is the producer of lincosamide-type
antibiotic lincomycin, a widely utilized drug against Gram-positive bacteria and protozoans …

AtrA belongs to the TetR family and has been well characterized for its roles in antibiotic
biosynthesis regulation. Here, we identified an AtrA homolog (AtrA-lin) in Streptomyces …

Aims Assessing the role of ramRsl, a gene absent in a lincomycin over‐producing strain, in
the regulation of morphological development and lincomycin biosynthesis in Streptomyces …

Lincomycin produced by Streptomyces lincolnensis is a critical antibacterial antibiotic in the
clinical. To further understand the regulatory mechanism of lincomycin biosynthesis, we …

In the post-genome era, great progress has been made in metabolic engineering using
recombinant DNA technology to enhance the production of high-value products by …