Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their
success is limited owing to insufficient efficacy and resistance. Recently, single-cell omics …

Tumours can obtain nutrients and oxygen required to progress and metastasize through the
blood supply. Inducing angiogenesis involves the sprouting of established vessel beds and …

Solid tumours comprise cancer cells that engage in continuous interactions with non-
malignant cells and with acellular components, forming the tumour microenvironment (TME) …

Brain metastasis (BrM) is a common malignancy, predominantly originating from lung,
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …

Strategies are needed to better identify patients that will benefit from immunotherapy alone
or who may require additional therapies like chemotherapy or radiotherapy to overcome …