Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Carbon-based materials, including graphene and carbon nanotubes, have been considered
attractive candidates for biomedical applications such as scaffolds in tissue engineering …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

Integrin adhesion receptors link the extracellular matrix (ECM) 1 to the actin cytoskeleton
and transmit biochemical signals and mechanical force across the plasma membrane. This …

Interactions of cells with the extracellular matrix are essential for the control of tissue
remodelling, cell migration, and embryogenesis. At the cell–extracellular matrix contact …

Talin is a structural component of focal adhesion sites and is thought to be engaged in
multiple protein interactions at the cytoplasmic face of cell/matrix contacts. Talin is a major …

The main purposes of Integrin-mediated cell contacts are to interpret bi-directional signals
between the extracellular environment and intracellular proteins, as well as, anchor the cell …

We have determined the sequence of chicken talin (2,541 amino acids, M r 271,881) which
is very similar (89% identity) to that of the mouse protein. Alignments with the …