The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

In female mammals, one of the two X chromosomes is silenced for dosage compensation
between the sexes. X-chromosome inactivation is initiated in early embryogenesis by the …

Recent studies have shown that defined sets of transcription factors can directly reprogram
differentiated somatic cells to a different differentiated cell type without passing through a …

The simple yet powerful technique of induced pluripotency may eventually supply a wide
range of differentiated cells for cell therapy and drug development. However, making the …

Reprogramming to induced pluripotent stem cells (iPSCs) proceeds in a stepwise manner
with reprogramming factor binding, transcription, and chromatin states changing during …

The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on
regulatory programs that govern self-renewal and differentiation and somatic cell …

Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs)
obtained using independent methods differ. Naive hPSCs have been mainly derived by …

Induction of pluripotency by transcription factors has become a commonplace method to
produce pluripotent stem cells. Great strides have been made in our understanding of the …

Cell banking, disease modeling, and cell therapy applications have placed increasing
demands on hiPSC technology. Specifically, the high-throughput derivation of footprint-free …

BACKGROUND: The diversity of cell types and tissue types that originate throughout
development derives from the differentiation potential of embryonic stem cells and somatic …