Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing
damaged materials and mobilizing energy reserves in conditions of starvation. Although …

Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti-
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Autoimmune hepatitis is characterized by autoantibodies, hypergammaglobulinemia, and
interface hepatitis on histological examination. The features lack diagnostic specificity, and …

S-adenosyl-l-methionine (SAMe; AdoMet) is an important, metabolically pleiotropic molecule
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …

Oxidative stress is commonly associated with a number of liver diseases and is thought to
play a role in the pathogenesis of chronic hepatitis C, alcoholic liver disease, non‐alcoholic …

BACKGROUND: Impaired signaling in the IFN-γ/IL-12 pathway causes susceptibility to
severe disseminated infections with mycobacteria and dimorphic yeasts. Dominant gain-of …

As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine
metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to …

Nonalcoholic fatty liver disease (NAFLD) is currently the most common liver disease
worldwide affecting over one-third of the population in the US It has been associated with …

Since its discovery in the early 1990s, the Janus kinase (JAK)-signal transducer and
activator of transcription (STAT) signaling pathway has been found to play key roles in …