Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Ubiquitylation is a widespread post-translational protein modification in eukaryotes and
marks bacteria that invade the cytosol as cargo for antibacterial autophagy,–. The identity of …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Mouse caspase-11 and human caspase-4 and caspase-5 recognize cytosolic
lipopolysaccharide (LPS) to induce pyroptosis by cleaving the pore-forming protein …

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …