[HTML][HTML] Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research

EK Elmahallawy, AAM Alkhaldi, AA Saleh - Biomedicine & …, 2021 - Elsevier
Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets

D Kumari, S Mahajan, P Kour, K Singh - Life sciences, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …

Leishmania species: A narrative review on surface proteins with structural aspects involved in host–pathogen interaction

RS Kaushal, N Naik, M Prajapati… - Chemical Biology & …, 2023 - Wiley Online Library
In tropical and subtropical regions of the world, leishmaniasis is endemic and causes a
range of clinical symptoms in people, from severe tegumentary forms (such as cutaneous …

Emerging strategies and challenges of molecular therapeutics in antileishmanial drug development

D Gupta, PK Singh, PK Yadav, T Narender… - International …, 2023 - Elsevier
Molecular therapy refers to targeted therapies based on molecules which have been
intelligently directed towards specific biomolecular structures and include small molecule …

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates

S Jain, U Sahu, A Kumar, P Khare - Pharmaceutics, 2022 - mdpi.com
Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …

[HTML][HTML] Evidence of a conserved mammalian immunosuppression mechanism in Lutzomyia longipalpis upon infection with Leishmania

EL Telleria, B Tinoco-Nunes, DM Forrest… - Frontiers in …, 2023 - frontiersin.org
Introduction Sand flies (Diptera: Phlebotominae) belonging to the Lutzomyia genus transmit
Leishmania infantum parasites. To understand the complex interaction between the vector …

Anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its Cu(II) and Ag(I) complexes

AKC Lima, CGR Elias, SSC Oliveira… - Parasitology …, 2021 - Springer
Leishmaniasis, included in the priority list of the WHO, remains as a neglected disease
caused by parasites of the Leishmania genus. There is no vaccine available for human …

[HTML][HTML] Bioinformatics evaluation of anticancer properties of GP63 protein-derived peptides on MMP2 protein of melanoma cancer

F Sharifi, I Sharifi, Z Babaei, S Alahdin… - Journal of Pathology …, 2023 - Elsevier
Background GP63, also known as Leishmanolysin, is a multifunctional virulence factor
abundant on the surface of Leishmania spp. small peptides with anticancer capabilities that …

Major Molecular Factors Related to Leishmania Pathogenicity

HS Al-Khalaifah - Frontiers in Immunology, 2022 - frontiersin.org
Leishmaniasis is a major health problem with 600k-1M new cases worldwide and 1 billion at
risk. It involves a wide range of clinical forms ranging from self-healing cutaneous lesions to …

Antiparasitic effect of leaf extract and major metabolites of Pelargonium quercetorum Agnew. against Leishmania major: in vitro and in silico studies

Y Maroufi, SR Hoseini, M Alavi - Journal of Applied Biotechnology …, 2022 - biotechrep.ir
Introduction: Leishmania is flagellate protozoa, the cause of leishmaniasis that has affected
more than 12 million people in 88 countries throughout the world. The aim of this study was …