Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

ME Abd El‐Hack, MT El‐Saadony… - Journal of the …, 2021 - Wiley Online Library
Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as
an aromatic stimulant, a food preservative, and coloring material. The commonly used …

Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview

L Huang, C Wu, H Gao, C Xu, M Dai, L Huang, H Hao… - Antibiotics, 2022 - mdpi.com
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

Defeating antibiotic-resistant bacteria: exploring alternative therapies for a post-antibiotic era

CH Wang, YH Hsieh, ZM Powers, CY Kao - International journal of …, 2020 - mdpi.com
Antibiotics are one of the greatest medical advances of the 20th century, however, they are
quickly becoming useless due to antibiotic resistance that has been augmented by poor …

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

H Venter, R Mowla, T Ohene-Agyei, S Ma - Frontiers in microbiology, 2015 - frontiersin.org
Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …

[HTML][HTML] Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification

AJ Seukep, V Kuete, L Nahar, SD Sarker… - Journal of pharmaceutical …, 2020 - Elsevier
The upsurge of multiple drug resistance (MDR) bacteria substantially diminishes the
effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure. The …

Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa

T Siriyong, P Srimanote, S Chusri… - … and alternative medicine, 2017 - Springer
Background Holarrhena antidysenterica has been employed as an ethnobotanical plant for
the treatment of dysentery, diarrhoea, fever, and bacterial infections. Biological activities of …

[HTML][HTML] Therapeutic potential and limitations of curcumin as antimetastatic agent

P Dytrych, Z Kejík, J Hajduch, R Kaplánek… - Biomedicine & …, 2023 - Elsevier
Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Efflux in Gram-negative bacteria: what are the latest opportunities for drug discovery?

T Gil-Gil, P Laborda, LE Ochoa-Sánchez… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Vanillin mediated green synthesis and application of gold nanoparticles for reversal of antimicrobial resistance in Pseudomonas aeruginosa clinical isolates

SS Arya, MM Sharma, RK Das, J Rookes, D Cahill… - Heliyon, 2019 - cell.com
Antimicrobial resistance (AMR) is a serious concern in pathogenic bacteria. As a new
approach to addressing AMR, we report here the green synthesis of vanillin capped gold …

Potential of Curcumin nanoemulsion as antimicrobial and wound healing agent in burn wound infection

M Kumari, DK Nanda - Burns, 2023 - Elsevier
The review article concentrates on the potential uses of curcumin nanoemulsion in treatment
and management of burn wound. Poor solubility and low bioavailability of curcumin limits …