Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

Joint pain is the hallmark symptom of osteoarthritis (OA) and the main reason for patients to
seek medical assistance. OA pain greatly contributes to functional limitations of joints and …

OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

Objective To systematically review the literature on the relationship between markers of
inflammation and pain in patients with knee osteoarthritis (OA). Methods We searched …

The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive.
While there have been successes in preclinical and early clinical studies, phase 3 clinical …

Objective To evaluate the role of immune cells and their effector cytokines in the
pathogenesis and progression of knee osteoarthritis (OA) in matched OA synovial fluid (SF) …

The aim of this study was to identify inflammatory mediators of potential clinical relevance in
synovial fluid (SF) samples of patients with knee osteoarthritis (OA). Therefore, radiographic …

Objective To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in
patients with hand osteoarthritis. Methods This was a multicentre, 12-week, randomised …