Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

The ability of vertebrates to 'remember'previous infections had once been attributed
exclusively to adaptive immunity. We now appreciate that innate lymphocytes also possess …

The transcription factors nuclear factor of activated T cells (NFAT) and activator protein 1 (AP-
1; Fos–Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence …

Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies,
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …

Improving effector activity of antigen-specific T cells is a major goal in cancer
immunotherapy. Despite the identification of several effector T cell (T EFF)-driving …

Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …

Memory T cells provide long-lasting defense responses through their ability to rapidly
reactivate, but how they efficiently “recall” an inflammatory transcriptional program remains …

Activated group 2 innate lymphoid cells (ILC2s) accumulate and promote inflammatory
resolution and tissue repair in host defense against acute respiratory viral infections …

Although the importance of genome organization for transcriptional regulation of cell-fate
decisions and function is clear, the changes in chromatin architecture and how these impact …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …