Advances on the Synthesis and Application of α, β-Unsaturated Nitrones

Z Ning, Q Xiaoting, W Zhixin, S Weimin… - Chinese Journal of …, 2021 - sioc-journal.cn
Nitrones, served as one of the most important 1, 3-dipoles in organic synthetic chemistry,
can participate in various organic synthetic reactions to synthesize various heterocyclic …

One-Step Synthesis of Hydropyrrolo[3,2-b]indoles via Cascade Reactions of Oxindole-Derived Nitrones with Allenoates

ML Luo, Q Hou, SJ Liu, Q Zhao, R Qin, C Peng… - Organic …, 2022 - ACS Publications
Hydropyrrolo [2, 3-b] indole is a privileged indoline motif, while its analogue, hydropyrrolo [3,
2-b] indole, has been much less explored. Herein, we developed a cascade reaction of …

One-Pot Synthesis of Multifunctionalized 1-Pyrrolines from 2-Alkyl-2H-azirines and Diazocarbonyl Compounds

IP Filippov, MS Novikov, AF Khlebnikov… - The Journal of …, 2022 - ACS Publications
A novel strategy for the synthesis of 1-pyrrolines based on formal [4+ 1] annulation of 2-alkyl-
2 H-azirines with diazocarbonyl compounds has been developed. This one-pot approach …

[4+ 1] Heteroannulation to Form 1‐Pyrrolines through Alder‐Ene Reaction of in situ Generated Ynimines: Development and Application in Total Synthesis of …

R Lavernhe, Q Wang, J Zhu - Angewandte Chemie, 2024 - Wiley Online Library
We report in this paper a novel Cu‐catalyzed synthesis of polysubstituted 1‐pyrrolines. The
reaction of β, γ‐unsaturated oxime esters 4 with terminal alkynes 5 in the presence of a …

Nitrosoarenes implement cascade cyclization of 1-Allenyl-2-alkynylbenzenes through diradical mechanism

C Maitra, PD Jadhav, D Barik, YS Ho, CC Cheng… - Organic …, 2022 - ACS Publications
This work reports cascade cyclization between 1-allenyl-2-alkynylbenzenes and
nitrosoarenes. When these two components reacted alone under N2, N, O-functionalized …

Copper-Catalyzed β-Lactam Formation Initiated by 1, 3-Azaprotio Transfer of Oximes and Methyl Propiolate

Z Qi, S Wang - Organic Letters, 2021 - ACS Publications
A copper (II)-catalyzed protocol to construct trans-configured β-lactams and spirocyclic β-
lactams from oximes and methyl propiolate has been developed, which features excellent …

Synthesis of Functionalized 2‐Pyrrolidinones Bearing N‐Trifluoromethylphenyl through A Formal [4+1] Cycloaddition of Cinnamaldehyde Nitrones and 1 …

C Wei, XL Cheng, YJ Chen, C Liang… - Advanced Synthesis & …, 2023 - Wiley Online Library
A variety of functionalized 2‐pyrrolidinones bearing N‐trifluoromethylphenyl moieties were
prepared in moderate to good yields with high diastereoselectivity through copper (II) …

The stannum–ene reactions of benzyne and cyclohexyne with superb chemoselectivity for cyclohexyne

L Li, C Shan, J Shi, W Li, Y Lan, Y Li - Angewandte Chemie, 2022 - Wiley Online Library
The stannum–ene reactions of both benzyne and cyclohexyne were realized, which is
particularly suitable for cyclohexyne with a broad substrate scope and excellent …

Gold-Catalyzed N-Alkenylation of Isoxazolines and the Use of Alkenyl Gold Intermediates in the Synthesis of 2-Amino-1-pyrrolines

AS Alshreimi, G Zhang, EJ Shim, DJ Wink… - ACS …, 2024 - ACS Publications
A gold-catalyzed method for N-alkenylation has been developed for NH-isoxazolines, which
are challenging substrates for alternative transition-metal-catalyzed N-functionalization …

DBU‐Promoted 6π‐Azaelectrocyclization and Hydrogen‐Migration to Prepare 6‐Alkyl Pyridine N‐Oxides from N‐Vinyl‐α,β‐Unsaturated Nitrones

N Zou, ZW Liu, GG Yan, YC Wang… - … Synthesis & Catalysis, 2022 - Wiley Online Library
We describe a DBU‐controlled 6π‐azaelectrocyclization of dibenzylideneacetone‐derived
N‐vinyl‐α, β‐unsaturated nitrones to prepare 6‐alkyl pyridine N‐oxides in 24–82% yields …