Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles

E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …

Advances in anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy

X Fang, J Cao, A Shen - Journal of Drug Delivery Science and Technology, 2020 - Elsevier
Breast cancer is one of the most common malignant tumors among women. Although the
traditional breast cancer therapies are effective, there have numerous shortcomings …

[HTML][HTML] Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

HS Han, SY Koo, KY Choi - Bioactive Materials, 2022 - Elsevier
Over thousands of years, natural bioactive compounds derived from plants (bioactive
phytocompounds, BPCs) have been used worldwide to address human health issues …

Fusion of tumor-derived exosomes with long-circulating and pH-sensitive liposomes loaded with doxorubicin for the treatment of breast cancer

ER Gomes, AT Carvalho, TC Barbosa, LL Ferreira… - AAPS …, 2022 - Springer
Doxorubicin (DOX) is a chemotherapeutic agent that has been used in the treatment of
breast cancer. However, serious toxic effects have limited its use, mainly cardiotoxicity. To …

Nanoliposomes as multidrug carrier of gemcitabine/paclitaxel for the effective treatment of metastatic breast cancer disease: a comparison with Gemzar and Taxol

C Celia, MC Cristiano, F Froiio… - Advanced …, 2021 - Wiley Online Library
Several liposomal drugs have received clinical approval for the treatment of cancer due to
the reduced side effects and/or improved therapeutic efficacy in comparison to their …

[HTML][HTML] Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes

B Zhai, Q Wu, W Wang, M Zhang, X Han… - Cancer biology & …, 2020 - ncbi.nlm.nih.gov
Objective: This study aimed to develop a new polyethylene glycol (PEG) ylated β-elemene
liposome (PEG-Lipo-β-E) and evaluate its characterization, pharmacokinetics, antitumor …

Achieving endo/lysosomal escape using smart nanosystems for efficient cellular delivery

N Desai, D Rana, S Salave, D Benival, D Khunt… - Molecules, 2024 - mdpi.com
The delivery of therapeutic agents faces significant hurdles posed by the endo-lysosomal
pathway, a bottleneck that hampers clinical effectiveness. This comprehensive review …

Engineered EV-mimetic nanoparticles as therapeutic delivery vehicles for high-grade serous ovarian cancer

AA Al-Dossary, EA Tawfik, AC Isichei, X Sun, J Li… - Cancers, 2021 - mdpi.com
Simple Summary In this review, we begin with the role of natural extracellular vesicles (EVs)
in high-grade serous ovarian cancer (HGSOC). Then, we narrow our focus on the …

Inhaled indomethacin-loaded liposomes as potential therapeutics against non-small cell lung cancer (NSCLC)

S Sarvepalli, V Parvathaneni, G Chauhan… - Pharmaceutical …, 2022 - Springer
Most lung cancer instances are non-small cell lung cancers (NSCLC). As stated by recent
literature, cycloxygenase-2 (COX-2) is upregulated in lung adenocarcinomas. COX-2 relates …

[HTML][HTML] Liposomes co-encapsulating doxorubicin and glucoevatromonoside derivative induce synergic cytotoxic response against breast cancer cell lines

MVM Novais, ER Gomes, MC Miranda, JO Silva… - Biomedicine & …, 2021 - Elsevier
Cancer is one of the main causes of death in the world and thus a global public health
problem. Among the treatments available for cancer are surgery, radiotherapy, and …