Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …
play an important role in the control of gene expression. In mammals, epigenetic …
Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges
The influence of diet and environment on human health has been known since ages. Plant-
derived natural bioactive compounds (phytochemicals) have acquired an important role in …
derived natural bioactive compounds (phytochemicals) have acquired an important role in …
Development of curcumin as an epigenetic agent
S Fu, R Kurzrock - Cancer, 2010 - Wiley Online Library
The clinical benefits of curcumin as a single agent were demonstrated in patients with
advanced pancreatic cancer in a phase 2 study despite pharmacokinetic analysis showing a …
advanced pancreatic cancer in a phase 2 study despite pharmacokinetic analysis showing a …
Epigenetic associations in relation to cardiovascular prevention and therapeutics
S Voelter-Mahlknecht - Clinical epigenetics, 2016 - Springer
Cardiovascular diseases (CVD) increasingly burden societies with vast financial and health
care problems. Therefore, the importance of improving preventive and therapeutic measures …
care problems. Therefore, the importance of improving preventive and therapeutic measures …
Curcuma as a parasiticidal agent: a review
Members of the Curcuma plant species (Zingiberaceae) have been used for centuries in
cooking, cosmetics, staining and in traditional medicine as “omnipotent” remedies. Herbal …
cooking, cosmetics, staining and in traditional medicine as “omnipotent” remedies. Herbal …
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
PN Mimche, D Taramelli, L Vivas - Malaria journal, 2011 - Springer
The clinical manifestations of cerebral malaria (CM) are well correlated with underlying
major pathophysiological events occurring during an acute malaria infection, the most …
major pathophysiological events occurring during an acute malaria infection, the most …
Toxoplasma histone acetylation remodelers as novel drug targets
Toxoplasma is able to differentiate from the rapidly replicating tachyzoite stage (active form)
into a latent cyst form (bradyzoite stage). The tachyzoite–bradyzoite interconversion includes …
into a latent cyst form (bradyzoite stage). The tachyzoite–bradyzoite interconversion includes …
Multifaceted roles of curcumin: two sides of a coin!
Introduction: Curcumin has been a front-line topic of mainstream scientific research for a
variety of diseases from cancer to Alzheimer's to infectious diseases. Curcumin suppresses …
variety of diseases from cancer to Alzheimer's to infectious diseases. Curcumin suppresses …
A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria
Background Nearly half of the world's population (3.2 billion people) were at risk of malaria
in 2015, and resistance to current therapies is a major concern. While the standard of care …
in 2015, and resistance to current therapies is a major concern. While the standard of care …
Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges
Tumorigenesis and epigenetic are closely linked with each other. Epigenetic changes are
potential regulators of gene expression without involving any change in the DNA itself. More …
potential regulators of gene expression without involving any change in the DNA itself. More …