The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Pathological mechanisms and therapeutic outlooks for arthrofibrosis

KM Usher, S Zhu, G Mavropalias, JA Carrino, J Zhao… - Bone research, 2019 - nature.com
Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Multiple roles of caspase-8 in cell death, inflammation, and innate immunity

P Orning, E Lien - Journal of Leucocyte Biology, 2021 - academic.oup.com
Caspase-8 is an apical caspase involved in the programmed form of cell death called
apoptosis that is critically important for mammalian development and immunity. Apoptosis …

IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation

P Jayaraman, I Sada-Ovalle, T Nishimura… - The Journal of …, 2013 - journals.aai.org
In vivo control of Mycobacterium tuberculosis reflects the balance between host immunity
and bacterial evasion strategies. Effector Th1 cells that mediate protective immunity by …

State of the art: the immunomodulatory role of MSCs for osteoarthritis

DG Kwon, MK Kim, YS Jeon, YC Nam, JS Park… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3

S Li, D Qi, J Li, X Deng, D Wang - Cell Death Discovery, 2021 - nature.com
The cholinergic anti-inflammatory pathway (CAIP) is important for antagonizing inflammation
and treating several diseases, including acute respiratory distress syndrome (ARDS), and is …

Elevated pre-activation basal level of nuclear NF-κB in native macrophages accelerates LPS-induced translocation of cytosolic NF-κB into the cell nucleus

AV Bagaev, AY Garaeva, ES Lebedeva, AV Pichugin… - Scientific reports, 2019 - nature.com
Signaling via Toll-like receptor 4 (TLR4) in macrophages constitutes an essential part of the
innate immune response to bacterial infections. Detailed and quantified descriptions of …

Curcumin suppresses NLRP3 inflammasome activation and protects against LPS‐induced septic shock

Z Gong, J Zhou, H Li, Y Gao, C Xu… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and
danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple …

[HTML][HTML] Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and …

YJ Chiu, CH Lin, MC Lee, HM Hsieh-Li… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Amyloid β (Aβ) plays a major role in the neurodegeneration of Alzheimer's disease (AD).
The accumulation of misfolded Aβ causes oxidative stress and inflammatory damage …

[HTML][HTML] Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

Z Gong, J Zhou, S Zhao, C Tian, P Wang, C Xu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Accumulation of hydrophobic bile acids in the liver contributes to cholestatic liver injury.
Inflammation induced by excessive bile acids is believed to play a crucial role, however, the …