Runs of homozygosity: current knowledge and applications in livestock

E Peripolli, DP Munari, M Silva, ALF Lima… - Animal …, 2017 - Wiley Online Library
This review presents a broader approach to the implementation and study of runs of
homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH …

Inbreeding depression in livestock species: review and meta‐analysis

G Leroy - Animal genetics, 2014 - Wiley Online Library
Inbreeding, by virtue of its consequence on traits of interest, is a topic of major interest for
geneticists and animal breeders. Based on meta‐analysis conducted on 57 studies and …

How to study runs of homozygosity using PLINK? A guide for analyzing medium density SNP data in livestock and pet species

R Meyermans, W Gorssen, N Buys, S Janssens - BMC genomics, 2020 - Springer
Background PLINK is probably the most used program for analyzing SNP genotypes and
runs of homozygosity (ROH), both in human and in animal populations. The last decade …

Inbreeding depression due to recent and ancient inbreeding in Dutch Holstein–Friesian dairy cattle

HP Doekes, RF Veerkamp, P Bijma, G de Jong… - Genetics Selection …, 2019 - Springer
Background Inbreeding decreases animal performance (inbreeding depression), but not all
inbreeding is expected to be equally harmful. Recent inbreeding is expected to be more …

Inbreeding and runs of homozygosity: A possible solution to an old problem

I Curik, M Ferenčaković, J Sölkner - Livestock science, 2014 - Elsevier
Quantifying human, plant and livestock inbreeding has been an important goal of
evolutionary biologists and agricultural scientists for nearly a century, and methods to do so …

Analysis of runs of homozygosity and their relationship with inbreeding in five cattle breeds farmed in Italy

G Marras, G Gaspa, S Sorbolini, C Dimauro… - Animal …, 2015 - Wiley Online Library
Increased inbreeding is an inevitable consequence of selection in livestock populations. The
analysis of high‐density single nucleotide polymorphisms (SNPs) facilitates the identification …

Inbreeding and runs of homozygosity before and after genomic selection in North American Holstein cattle

M Forutan, S Ansari Mahyari, C Baes, N Melzer… - BMC genomics, 2018 - Springer
Background While autozygosity as a consequence of selection is well understood, there is
limited information on the ability of different methods to measure true inbreeding. In the …

Identification of genomic regions associated with inbreeding depression in Holstein and Jersey dairy cattle

JE Pryce, M Haile-Mariam, ME Goddard… - Genetics Selection …, 2014 - Springer
Background Inbreeding reduces the fitness of individuals by increasing the frequency of
homozygous deleterious recessive alleles. Some insight into the genetic architecture of …

A publicly available repository of ROH islands reveals signatures of selection in different livestock and pet species

W Gorssen, R Meyermans, S Janssens… - Genetics Selection …, 2021 - Springer
Background Runs of homozygosity (ROH) have become the state-of-the-art method for
analysis of inbreeding in animal populations. Moreover, ROH are suited to detect signatures …

Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds

Q Zhang, MPL Calus, B Guldbrandtsen, MS Lund… - BMC genetics, 2015 - Springer
Background Levels of inbreeding in cattle populations have increased in the past due to the
use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to …