The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a
powerful karyotyping tool in numerous translational cancer studies. SNP-A complements …

Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic
leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to …

The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide
hydroxamic acid, SAHA) were evaluated in patients with refractory cutaneous T-cell …

Context Chromosomal abnormalities (namely 13q, 17p, and 11q deletions) have prognostic
implications and are recurrent in chronic lymphocytic leukemia (CLL), suggesting that they …

Patients with chromosome 13q deletion or normal cytogenetics represent the majority of
chronic lymphocytic leukaemia (CLL) cases, yet have relatively few driver mutations. To …

In CLL data from chromosome banding analysis (CBA) have been scarce due to the low
proliferative activity of CLL cells in vitro. We improved the cultivation technique using an …

We conducted a genome-wide association study of 299,983 tagging SNPs for chronic
lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 …

Enhancer profiling is a powerful approach for discovering cis-regulatory elements that define
the core transcriptional regulatory circuits of normal and malignant cells. Gene control …

Using metaphase cytogenetics (MC), chromosomal abnormalities are found in only a
proportion of patients with myelodysplastic syndrome (MDS). We hypothesized that with new …