The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

Bioengineering of ribosomally synthesized and post-translationally modified peptides
(RiPPs) is an emerging approach to explore the diversity of pseudo-natural product …

Broad substrate tolerance of ribosomally synthesized and post-translationally modified
peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP …

Macrocyclic peptides are promising scaffolds for the covalent ligand discovery. However,
platforms enabling the direct identification of covalent macrocyclic ligands in a high …

Extremely diverse libraries are essential for effectively selecting functional peptides or
proteins, and mRNA display technology is a powerful tool for generating such libraries with …

Promiscuous post-translational modification (PTM) enzymes often display nonobvious
substrate preferences by acting on diverse yet well-defined sets of peptides and/or proteins …

Despite the advances in surface-display systems for directed evolution, variants with high
affinity are not always enriched due to undesirable biases that increase target-unrelated …

In recent years, an increasing number of drug-resistant bacterial strains have been identified
due to the abuse of antibiotics, which seriously threatens human and animal health …

Therapeutic monoclonal antibodies directed against PD-L1 (eg, atezolizumab) disrupt PD-
L1: PD-1 signaling and reactivate exhausted cytotoxic T-cells in the tumor compartment …