Histone post-translational modifications—cause and consequence of genome function

G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Molecular mechanisms of environmental exposures and human disease

H Wu, CM Eckhardt, AA Baccarelli - Nature Reviews Genetics, 2023 - nature.com
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

[HTML][HTML] Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature Communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Bridging the explanatory gaps: What can we learn from a biological agency perspective?

SE Sultan, AP Moczek, D Walsh - BioEssays, 2022 - Wiley Online Library
We begin this article by delineating the explanatory gaps left by prevailing gene‐focused
approaches in our understanding of phenotype determination, inheritance, and the origin of …

Soma-to-germline RNA communication

CC Conine, OJ Rando - Nature Reviews Genetics, 2022 - nature.com
More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

Sex differences in the intergenerational inheritance of metabolic traits

I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

[HTML][HTML] Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction

AS Pepin, C Lafleur, R Lambrot, V Dumeaux… - Molecular …, 2022 - Elsevier
Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …

[HTML][HTML] Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?

L Gaspa-Toneu, AHFM Peters - Current Opinion in Genetics & …, 2023 - Elsevier
The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Multigenerational epigenetic inheritance: Transmitting information across generations

NO Burton, EL Greer - Seminars in cell & developmental biology, 2022 - Elsevier
Inherited epigenetic information has been observed to regulate a variety of complex
organismal phenotypes across diverse taxa of life. This continually expanding body of …

Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms

F Santilli, A Boskovic - Current Opinion in Genetics & Development, 2023 - Elsevier
Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …