Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

We begin this article by delineating the explanatory gaps left by prevailing gene‐focused
approaches in our understanding of phenotype determination, inheritance, and the origin of …

More than a century ago, August Weissman defined a distinction between the germline
(responsible for propagating heritable information from generation to generation) and the …

Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Inherited epigenetic information has been observed to regulate a variety of complex
organismal phenotypes across diverse taxa of life. This continually expanding body of …

Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …