Histone post-translational modifications—cause and consequence of genome function
G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
[HTML][HTML] Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
Bridging the explanatory gaps: What can we learn from a biological agency perspective?
We begin this article by delineating the explanatory gaps left by prevailing gene‐focused
approaches in our understanding of phenotype determination, inheritance, and the origin of …
approaches in our understanding of phenotype determination, inheritance, and the origin of …
Sex differences in the intergenerational inheritance of metabolic traits
I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …
including those in utero, influence our long-term metabolic health. This has been termed …
[HTML][HTML] Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction
Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …
[HTML][HTML] Nucleosomes in mammalian sperm: conveying paternal epigenetic inheritance or subject to reprogramming between generations?
L Gaspa-Toneu, AHFM Peters - Current Opinion in Genetics & …, 2023 - Elsevier
The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …
protamines. The presence of some residual nucleosomes has, however, emerged as a …
Multigenerational epigenetic inheritance: Transmitting information across generations
Inherited epigenetic information has been observed to regulate a variety of complex
organismal phenotypes across diverse taxa of life. This continually expanding body of …
organismal phenotypes across diverse taxa of life. This continually expanding body of …
Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms
F Santilli, A Boskovic - Current Opinion in Genetics & Development, 2023 - Elsevier
Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …
parental germline epigenome modulate phenotypic output in one or more subsequent …