[HTML][HTML] CD8+ T Cell Exhaustion in Cancer
JS Dolina, N Van Braeckel-Budimir… - Frontiers in …, 2021 - frontiersin.org
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …
underway. Originally thought to be a uniform population that progressively loses effector …
[HTML][HTML] Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations
JA Seidel, A Otsuka, K Kabashima - Frontiers in oncology, 2018 - frontiersin.org
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
[HTML][HTML] The role of PD-1 in acute and chronic infection
JM Jubel, ZR Barbati, C Burger, DC Wirtz… - Frontiers in …, 2020 - frontiersin.org
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
Overcoming T cell exhaustion in infection and cancer
Inhibitors of the Programmed Cell Death 1: Programmed Cell Death 1 ligand 1 (PD-1: PD-
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
Is autoimmunity the Achilles' heel of cancer immunotherapy?
CH June, JT Warshauer, JA Bluestone - Nature medicine, 2017 - nature.com
The emergence of immuno-oncology as the first broadly successful strategy for metastatic
cancer will require clinicians to integrate this new pillar of medicine with chemotherapy …
cancer will require clinicians to integrate this new pillar of medicine with chemotherapy …
[HTML][HTML] The immunoreceptor TIGIT regulates antitumor and antiviral CD8+ T cell effector function
Tumors constitute highly suppressive microenvironments in which infiltrating T cells are"
exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory …
exhausted" by inhibitory receptors such as PD-1. Here we identify TIGIT as a coinhibitory …
Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1‐6 hepatocellular carcinoma model
T Kimura, YU Kato, Y Ozawa, K Kodama, J Ito… - Cancer …, 2018 - Wiley Online Library
Angiogenesis inhibitors such as lenvatinib and sorafenib, and an immune checkpoint
inhibitor (ICI), nivolumab, are used for anticancer therapies against advanced hepatocellular …
inhibitor (ICI), nivolumab, are used for anticancer therapies against advanced hepatocellular …
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
B Sangro, C Gomez-Martin, M de la Mata… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Tremelimumab is a monoclonal antibody that blocks cytotoxic T-
lymphocyte-associated antigen 4 (CTLA-4), an inhibitory co-receptor that interferes with T …
lymphocyte-associated antigen 4 (CTLA-4), an inhibitory co-receptor that interferes with T …
T cell exhaustion
EJ Wherry - Nature immunology, 2011 - nature.com
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
AL Doedens, AT Phan, MH Stradner, JK Fujimoto… - Nature …, 2013 - nature.com
Cytolytic activity by CD8+ cytotoxic T lymphocytes (CTLs) is a powerful strategy for the
elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is …
elimination of intracellular pathogens and tumor cells. The destructive capacity of CTLs is …