The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
History and function of the lactate receptor GPR81/HCAR1 in the brain: a putative therapeutic target for the treatment of cerebral ischemia
ACM Colucci, IDÁ Tassinari, E da Silveira Loss… - Neuroscience, 2023 - Elsevier
GPR81 is a G-protein coupled receptor (GPCR) discovered in 2001, but deorphanized only
7 years later, when its affinity for lactate as an endogenous ligand was demonstrated. More …
7 years later, when its affinity for lactate as an endogenous ligand was demonstrated. More …
Sensitive multicolor indicators for monitoring norepinephrine in vivo
Genetically encoded indicators engineered from G-protein-coupled receptors are important
tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a …
tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a …
Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
O Coskuner-Weber, O Mirzanli, VN Uversky - Biophysical Reviews, 2022 - Springer
Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …
regions are associated with neurodegenerative diseases. These types of proteins including …
Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …
Recent advances in structure-based drug design targeting class AG protein-coupled receptors utilizing crystal structures and computational simulations
G protein-coupled receptors (GPCRs) represent the largest and most physiologically
important integral membrane protein family, and these receptors respond to a wide variety of …
important integral membrane protein family, and these receptors respond to a wide variety of …
lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
Y Jiang, H Guo, T Tong, F Xie, X Qin, X Wang, W Chen… - Molecular Therapy, 2022 - cell.com
Cisplatin resistance is a major therapeutic challenge in advanced head and neck squamous
cell carcinoma (HNSCC). Here, we aimed to investigate the key signaling pathway for …
cell carcinoma (HNSCC). Here, we aimed to investigate the key signaling pathway for …
Gonadotropin-releasing hormone (GnRH) receptor structure and GnRH binding
CA Flanagan, A Manilall - Frontiers in endocrinology, 2017 - frontiersin.org
Gonadotropin-releasing hormone (GnRH) regulates reproduction. The human GnRH
receptor lacks a cytoplasmic carboxy-terminal tail but has amino acid sequence motifs …
receptor lacks a cytoplasmic carboxy-terminal tail but has amino acid sequence motifs …
Phylogenetic utility of rRNA ITS2 sequence-structure under functional constraint
W Zhang, W Tian, Z Gao, G Wang, H Zhao - International Journal of …, 2020 - mdpi.com
The crucial function of the internal transcribed spacer 2 (ITS2) region in ribosome
biogenesis depends on its secondary and tertiary structures. Despite rapidly evolving, ITS2 …
biogenesis depends on its secondary and tertiary structures. Despite rapidly evolving, ITS2 …
Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists
The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor
(GPCR), which belongs to the class C family that also includes the metabotropic glutamate …
(GPCR), which belongs to the class C family that also includes the metabotropic glutamate …