Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

High-throughput experimentation is a common practice in the optimization of chemical
synthesis. Chemists design reaction arrays to optimize the yield of couplings between …

Miniaturization is a tactic employed in many technologies to accelerate discovery through
parallelized data collection. The miniaturization of chemical synthesis to the limits of …

With the advent of high-throughput methods for both computation and experimentation, data-
rich approaches to discovering and understanding chemical reactions are becoming ever …

The chemical and reaction spaces are incredibly vast and special procedures are required
to study them. Their complex and multiparametric nature encompass myriads of compounds …

DNA-encoded library technology grants access to nearly infinite opportunities to explore the
chemical structure space for drug discovery. Successful navigation depends on the design …

Enzyme inhibitors working by O-acylation of nucleophilic serine residues are of immense
medicinal importance, as exemplified by the β-lactam antibiotics. By contrast, inhibition of …

The cycle time of a standard liquid chromatography (LC) system is the sum of the time for the
chromatographic run and the autosampler injection sequence. Although LC separation …

Abstract The SARS-CoV-2 papain-like protease (PL pro) and main protease (M pro) are
nucleophilic cysteine enzymes that catalyze the hydrolysis of the viral polyproteins …

Inspired by the multicomponent reaction-type scenario involving fatty dialdehydes, a
nitrogen source, and acrolein, as a key C3 unit, put forward by Baldwin and Whitehead to …