Are we meeting the promise of endotypes and precision medicine in asthma?

A Ray, M Camiolo, A Fitzpatrick… - Physiological …, 2020 - journals.physiology.org
While the term asthma has long been known to describe heterogeneous groupings of
patients, only recently have data evolved which enable a molecular understanding of the …

New perspectives in the diagnosis and management of allergic fungal airway disease

AJ Wardlaw, EM Rick, L Pur Ozyigit… - Journal of Asthma …, 2021 - Taylor & Francis
Allergy to airway-colonising, thermotolerant, filamentous fungi represents a distinct
eosinophilic endotype of often severe lung disease. This endotype, which particularly affects …

Attenuation of ovalbumin-induced inflammation and lung oxidative injury in asthmatic rats by Zingiber officinale extract: combined in silico and in vivo study on antioxidant …

O Jedli, H Ben-Nasr, N Zammel, T Rebai, M Saoudi… - 3 Biotech, 2022 - Springer
In the present study we focused on the anti-asthmatic and antioxidant effects of Zingiber
officinalis roscoe L.(ZO) aqueous extract. This study includes 20 adult male rats, which were …

[HTML][HTML] Airway microbiota in children with bronchial mucus plugs caused by Mycoplasma pneumoniae pneumonia

X Xu, L Wu, Y Sheng, J Liu, Z Xu, W Kong, L Tang… - Respiratory …, 2020 - Elsevier
Background There is increasing evidence for a role of lung microbiota in the pathogenesis of
Mycoplasma pneumoniae pneumonia (MPP). However, the alterations of lung microbiota in …

Update on the Role of Fungus in Allergy, Asthma, and the Unified Airway

BH Cameron, SW Gong, DB Corry… - … Clinics of North …, 2023 - oto.theclinics.com
The unified airway refers to the combined upper and lower airways and their shared
pathophysiologic relationships. These 2 systems are thought to be interconnected, and …

[HTML][HTML] Pulmonary Mycosis Drives Forkhead Box Protein A2 Degradation and Mucus Hypersecretion Through Activation of the Spleen Tyrosine Kinase–Epidermal …

W Choi, AX Yang, A Sieve, SH Kuo… - The American Journal of …, 2021 - Elsevier
Pulmonary mycoses are difficult to treat and detrimental to patients. Fungal infections
modulate the lung immune response, induce goblet cell hyperplasia and metaplasia, and …

Airway mucus, infection, and therapeutic strategies

M NandyMazumdar - Viral, Parasitic, Bacterial, and Fungal Infections, 2023 - Elsevier
The respiratory tract epithelium is hydrated by a mucous layer, which forms a protective
barrier for the defense against sometimes life-threatening foreign particles, including …

[HTML][HTML] Humoral first-line mucosal innate defence in vivo

C Persson - Journal of Innate Immunity, 2020 - karger.com
Based on observations in vivo in guinea-pig and human airways, this review presents
plasma exudation as non-sieved transmission of bulk plasma across an unperturbed …

The Role of the Microbiome in Asthma Inception and Phenotype

SR White, YJ Huang - The Microbiome in Respiratory Disease: Principles …, 2022 - Springer
The lung microbiome in adult asthma is the product of a long period of dynamic shaping by
microorganisms and the host from infancy onwards. The use of next-generation sequencing …

[HTML][HTML] Chair's summary: secreted mucins in lung diseases

BF Dickey - Annals of the American Thoracic Society, 2018 - atsjournals.org
The 33rd Transatlantic Airway Conference was held January 17–19, 2018, in Lucerne,
Switzerland. The topic of this year's conference was the protective and pathologic roles of …