The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions
are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein …

The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the
endoplasmic reticulum and the plasma membrane of some mammalian cells. The S1R is …

The remodeling of calcium homeostasis contributes to the cancer hallmarks and the
molecular mechanisms involved in calcium channel regulation in tumors remain to be …

Sigma-1 receptor (S1R) is a mammalian member of the ERG2 and sigma-1 receptor-like
protein family (pfam04622). It has been implicated in drug addiction and many human …

Sigma1 receptors (σ1Rs) are expressed widely; they bind diverse ligands, including
psychotropic drugs and steroids, regulate many ion channels, and are implicated in cancer …