Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

Cortico-striatal projections are critical components of forebrain circuitry that regulate
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads
to the aberrant formation of protein aggregates and the differential degeneration of striatal …

Summary X-linked Dystonia-Parkinsonism (XDP) is a Mendelian neurodegenerative
disease that is endemic to the Philippines and is associated with a founder haplotype. We …

Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG
repeat expansion in HTT. Here we report correction of HD human induced pluripotent stem …

A variety of neurological disorders are attractive targets for stem and progenitor cell-based
therapy. Yet many conditions are not, whether by virtue of an inhospitable disease …

Huntington's disease (HD) is an inherited neurodegenerative disease caused by an
expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half …

Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …