Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of
PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and
amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain …

Autosomal recessively inherited glucocerebrosidase 1 (GBA1) mutations cause the
lysosomal storage disorder Gaucher's disease (GD). Heterozygous GBA1 mutations …

A wide variety of human diseases have been modelled in zebrafish, including various types
of cancer, cardiovascular diseases and neurodegenerative diseases like Alzheimer's and …

Neurodegenerative diseases are a group of nervous system conditions characterised
pathologically by the abnormal deposition of protein throughout the brain and spinal cord …