Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance
and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and …

Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity,
type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in …

The prevalence and severity of obesity have increased in recent years, likely the result of
complex interactions between genes, dietary intake, physical activity, and the environment …

The presence of obesity-related metabolic disturbances varies widely among obese
individuals. Accordingly, a unique subset of obese individuals has been described in the …

Context Although the prevalence rates of childhood obesity have seemingly been stable
over the past few years, far too many children and adolescents are still obese. Childhood …

Background: Prospective longitudinal studies evaluating the relevance of “Metabolically
Healthy but Obese”(MHO) phenotype at risk for type 2 diabetes mellitus (T2D) and …

Childhood obesity is a significant health problem that has reached epidemic proportions
around the world and is associated with several metabolic and cardiovascular …

Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

Obesity in childhood is the main determinant of whole body reduced insulin sensitivity. This
association has been demonstrated in multiple adult and pediatric cohorts. The mechanistic …