Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global
health care priority. Some analyses, including the O'Neill report, have predicted that deaths …

Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately,
the limited number of antifungal options is exacerbated by the continuous emergence of …

Human fungal pathogens are the causative agents of devastating diseases across the
globe, and the increasing prevalence of drug resistance threatens to undermine the already …

For the human fungal pathogen Candida albicans, metabolic flexibility and the ability to
transition between yeast and filamentous growth states are key virulence traits that enable …

Prediction of orthologs is an important bioinformatics pursuit that is frequently used for
inferring protein function and evolutionary analyses. The InParanoid database is a well …

Highlights•Fungi have a serious impact on human health, causing millions of deaths
worldwide.•Scientific advances have enabled the discovery of novel antifungals.•This review …

Genome-scale metabolic models are powerful tools for understanding cellular physiology.
Flux balance analysis (FBA), in particular, is an optimization-based approach widely …

For the fungal pathogen Candida albicans, genetic overexpression readily occurs via a
diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with …