Alkylating agents‐induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front

S Sriram, T Macedo… - Clinical and …, 2024 - Wiley Online Library
Rising cure rates in pediatric cancer patients warrants an increased attention toward the
long‐term consequences of the diagnosis and treatment in survivors. Chemotherapeutic …

[HTML][HTML] Testicular and haematological cancer induce very high levels of sperm oxidative stress

C Calamai, O Ammar, V Rosta, G Farnetani, S Zimmitti… - Antioxidants, 2023 - mdpi.com
Cancer impairs spermatogenesis, whereas results on sperm DNA integrity are controversial
and no data are available about sperm oxidative stress. In cancer patients, we detected …

Severe sperm DNA fragmentation may persist for up to 3 years after cytotoxic therapy in patients affected by Hodgkin lymphoma and non-Hodgkin lymphoma

G Farnetani, M Vannucci, MG Fino, F Cioppi… - Human …, 2024 - academic.oup.com
Abstract STUDY QUESTION Does sperm DNA recover from damage in all men after 2 years
from the end of cytotoxic treatments? SUMMARY ANSWER The current indication of 2 years …

[引用][C] Sperm DNA integrity: A special issue exploring the causes, consequences, and treatment of DNA damage in human spermatozoa

RJ Aitken - Andrology, 2023 - Wiley Online Library
Since the pioneering studies by Don Evenson and colleagues first opened our eyes to the
existence of DNA damage in subpopulations of human spermatozoa, 1 important questions …