Quinoline hybrids and their antiplasmodial and antimalarial activities

YQ Hu, C Gao, S Zhang, L Xu, Z Xu, LS Feng… - European Journal of …, 2017 - Elsevier
Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Enhancing the antimalarial activity of artesunate

JO Adebayo, H Tijjani, AP Adegunloye, AA Ishola… - Parasitology …, 2020 - Springer
The global challenge to the treatment of malaria is mainly the occurrence of resistance of
malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic …

Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation

VV Kouznetsov, A Gómez-Barrio - European journal of medicinal chemistry, 2009 - Elsevier
A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …

The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines

L CS Pinheiro, L M. Feitosa, M O. Gandi, F F. Silveira… - Molecules, 2019 - mdpi.com
Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …

Testing of natural products and synthetic molecules aiming at new antimalarials

AU Krettli, JO Adebayo, LG Krettli - Current drug targets, 2009 - ingentaconnect.com
The search for new antimalarials, which in the past relied on animal models, is now usually
performed with cultures of Plasmodium falciparum (PF) blood parasites by evaluation of …

[HTML][HTML] Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives

L Pinheiro, LM Feitosa, FF SILVEIRA… - Anais da Academia …, 2018 - SciELO Brasil
ABSTRACT According to the World Health Organization, malaria remains one of the biggest
public health problems in the world. The development of resistance is a current concern …

Current progress in antimalarial pharmacotherapy and multi-target drug discovery

NS Tibon, CH Ng, SL Cheong - European journal of medicinal chemistry, 2020 - Elsevier
Discovery and development of antimalarial drugs have long been dominated by single-
target therapy. Continuous effort has been made to explore and identify different targets in …

Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds

GC Brandão, FCR Missias, LM Arantes… - European journal of …, 2018 - Elsevier
Lapachol is an abundant prenyl naphthoquinone occurring in Brazilian Bignoniaceae that
was clinically used, in former times, as an antimalarial drug, despite its moderate effect …

Antimalarial peroxides: advances in drug discovery and design

RD Slack, AM Jacobine, GH Posner - MedChemComm, 2012 - pubs.rsc.org
Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …