Volume overload is an important clinical target in heart failure management, typically
addressed using loop diuretics. An important and challenging subset of heart failure patients …

Because of various pharmacodynamic properties, such as the nonlinearity of the
concentration-effect relationship, activation of feedback homeostatic mechanisms, induction …

Background Fluid and sodium overload are a common problem in critically ill patients.
Frusemide may result in diuresis in excess of natriuresis. The addition of indapamide may …

BACKGROUND In patients with respiratory failure, loop diuretics remain the cornerstone of
the treatment to maintain fluid balance, but resistance is common. AIM To determine the …

Background There is a paucity of evidence on the association between preoperative
diuretics use and outcomes following cardiac surgery. We hypothesized that diuretic use …

Objective: To review the literature regarding the efficacy and safety of continuous
intravenous infusion of loop diuretics following cardiac surgery. Data Sources: Articles were …

Purpose The results of a study to determine the stability of solutions of furosemide and
chlorothiazide over 96 hours are reported. Methods Chlorothiazide and furosemide were …

Study Objective To assess the efficacy of intravenous chlorothiazide in patients with acute
decompensated heart failure (ADHF) who were determined to be loop diuretic resistant and …

Background. Routine diuretic administration after cardiopulmonary bypass is common
despite the lack of evidence for its benefit. We performed a prospective study to evaluate if …

OBJECTIVES Postoperative fluid overload is ubiquitous in neonates and infants following
operative intervention for congenital heart defects; ineffective diuresis is associated with …