Materials and methods for treatment of human genetic diseases including hemoglobinopathies
MH Porteus - US Patent 12,129,471, 2024 - Google Patents
YIJVOACVHQZMKI-JXOAFFINSA-N [[(2r, 3s, 4r, 5r)-5-(4-amino-5-methyl-2-oxopyrimidin-1-
yl)-3, 4-dihydroxyoxolan-2-yl] methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate …
yl)-3, 4-dihydroxyoxolan-2-yl] methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate …
Materials and methods for treatment of hemoglobinopathies
MH Porteus, MR Allen, CA Cowan… - US Patent …, 2024 - Google Patents
The present application provides materials and methods for treating hemoglobinopathies.
More specifically, the application provides methods for producing progenitor cells that are …
More specifically, the application provides methods for producing progenitor cells that are …
Materials and methods for treatment of hemoglobinopathies
MH Porteus - US Patent 10,738,305, 2020 - Google Patents
The present application provides materials and methods for treating hemoglobinopathies.
More specifically, the applica tion provides methods for producing progenitor cells that are …
More specifically, the applica tion provides methods for producing progenitor cells that are …
Methods and systems for guide rna design and use
R Stoner, T Maures, D Conant - US Patent 11,345,932, 2022 - Google Patents
US11345932B2 - Methods and systems for guide RNA design and use - Google Patents
US11345932B2 - Methods and systems for guide RNA design and use - Google Patents …
US11345932B2 - Methods and systems for guide RNA design and use - Google Patents …
Gene-regulating compositions and methods for improved immunotherapy
M Benson, J Merkin, GV Kryukov, SM Shenker… - US Patent …, 2021 - Google Patents
The present disclosure provides methods and compositions related to the modification of
immune effector cells to increase therapeutic efficacy. In some embodiments, immune …
immune effector cells to increase therapeutic efficacy. In some embodiments, immune …
Gene-regulating compositions and methods for improved immunotherapy
M Benson, JJ Merkin, GV Kryukov… - US Patent …, 2022 - Google Patents
The present disclosure provides methods and compositions related to the modification of
immune effector cells to increase therapeutic efficacy. In some embodiments, immune …
immune effector cells to increase therapeutic efficacy. In some embodiments, immune …
Gene-regulating compositions and methods for improved immunotherapy
M Benson, JJ Merkin, GV Kryukov… - US Patent …, 2023 - Google Patents
US11608500B2 - Gene-regulating compositions and methods for improved immunotherapy -
Google Patents US11608500B2 - Gene-regulating compositions and methods for improved …
Google Patents US11608500B2 - Gene-regulating compositions and methods for improved …
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
C Cotta-Ramusino, CM Margulies - US Patent 11,866,726, 2024 - Google Patents
US11866726B2 - Systems and methods for targeted integration and genome editing and
detection thereof using integrated priming sites - Google Patents US11866726B2 - Systems …
detection thereof using integrated priming sites - Google Patents US11866726B2 - Systems …
Materials and methods for treatment of hemoglobinopathies
MH Porteus - US Patent 12,134,767, 2024 - Google Patents
QCBCPALLWXTPLW-SFHVURJKSA-N (2S)-2-(3, 4-dihydroxyphenyl)-8, 8-dimethyl-2, 3, 9,
10-tetrahydropyrano [2, 3-h] chromen-4-one Chemical compound C1 ([C@@ H] 2CC (= O) …
10-tetrahydropyrano [2, 3-h] chromen-4-one Chemical compound C1 ([C@@ H] 2CC (= O) …
Methods for targeted insertion of DNA in genes
NJ Baltes - US Patent 11,254,930, 2022 - Google Patents
Monogenic disorders are caused by one or more mutations in a single gene, examples of
which include sickle cell disease (hemoglobin-beta gene), cystic fibrosis (cystic fibrosis …
which include sickle cell disease (hemoglobin-beta gene), cystic fibrosis (cystic fibrosis …