In the last decades, the number of patients receiving chemotherapy has considerably
increased. Given the toxicity of cytotoxic agents to humans (not only for patients but also for …

Chromatographic stationary phases based on porous graphitic carbon were invented 30
years ago, while columns have been commercially available for 20 years. This special …

The characterization of glycosylation is critical for obtaining a comprehensive view of the
regulation and functions of glycoproteins of interest. Due to the complex nature of …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for hydride transfer reactions and
a substrate for sirtuins and other NAD+-consuming enzymes. The abundance of NAD+ …

Hydrophilic-interaction liquid chromatography (HILIC), reversed-phase chromatography
(RPC) and porous graphitic carbon (PGC) chromatography are typically applied for liquid …

The wide variety of chemical properties and biological functions found in proteins is attained
via post‐translational modifications like glycosylation. Covalently bonded to proteins …

We examined the analysis of nucleotides and nucleotide sugars by chromatography on
porous graphitic carbon with mass spectrometric detection, a method that evades …

Background Glycosaminoglycans (GAGs) are negatively charged polysaccharides present,
eg, on the luminal face of the blood vessels as heparan sulphate (HS) and hyaluronic acid …

An ion-pairing reversed-phase liquid chromatography–mass spectrometry (IP-RP-LC–MS)
was developed for the determination of nucleotides, nucleosides and their transformation …

Porous graphitic carbon (PGC) is an important tool in a chromatographer's armory that
retains polar compounds with mass spectrometry (MS)-compatible solvents. However, its …