Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons
A Ramesh, SA Walker, DB Hood… - … journal of toxicology, 2004 - journals.sagepub.com
Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the
environment. These contaminants generate considerable interest, because some of them …
environment. These contaminants generate considerable interest, because some of them …
Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective
DL Diggs, AC Huderson, KL Harris… - … science and health …, 2011 - Taylor & Francis
Cancers of the colon are most common in the Western world. In majority of these cases,
there is no familial history and sporadic gene damage seems to play an important role in the …
there is no familial history and sporadic gene damage seems to play an important role in the …
The Cigarette Smoke Carcinogen Benzo[a]pyrene Enhances Human Papillomavirus Synthesis
S Alam, MJ Conway, HS Chen, C Meyers - Journal of virology, 2008 - Am Soc Microbiol
Epidemiological studies suggest that cigarette smoke carcinogens are cofactors which
synergize with human papillomavirus (HPV) to increase the risk of cervical cancer …
synergize with human papillomavirus (HPV) to increase the risk of cervical cancer …
Gap junctions as targets for cancer chemoprevention and chemotherapy
JE Trosko, RJ Ruch - Current Drug Targets, 2002 - ingentaconnect.com
The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
Green potential of Pleurotus spp. in biotechnology
AS Sekan, OS Myronycheva, O Karlsson… - PeerJ, 2019 - peerj.com
Background The genus Pleurotus is most exploitable xylotrophic fungi, with valuable
biotechnological, medical, and nutritional properties. The relevant features of the …
biotechnological, medical, and nutritional properties. The relevant features of the …
The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional …
Modulation of gap junctional intercellular communication (GJIC) is a known cellular event
associated with tumor promotion. The present study was undertaken to test the potential …
associated with tumor promotion. The present study was undertaken to test the potential …
The emperor wears no clothes in the field of carcinogen risk assessment: ignored concepts in cancer risk assessment
JE Trosko, BL Upham - Mutagenesis, 2005 - academic.oup.com
The following is a position paper challenging the paradigm that 'carcinogen= mutagen', and
that the current rodent bioassay to predict risks to human cancers is relevant and useful …
that the current rodent bioassay to predict risks to human cancers is relevant and useful …
Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons
L Bláha, P Kapplová, J Vondráček… - Toxicological …, 2002 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) are a broad class of ubiquitous environmental
pollutants with known or suspected carcinogenic properties. Tumor promotion is a cell …
pollutants with known or suspected carcinogenic properties. Tumor promotion is a cell …
Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen …
M Machala, L Bláha, HJ Lehmler… - Chemical research in …, 2004 - ACS Publications
In the present study, a series of 32 hydroxy-and dihydroxy-polychlorinated biphenyls (OH-
PCBs) and PCB-derived quinones were prepared and evaluated for their in vitro potencies …
PCBs) and PCB-derived quinones were prepared and evaluated for their in vitro potencies …
Applicability of scrape loading-dye transfer assay for non-genotoxic carcinogen testing
I Sovadinová, BL Upham, JE Trosko… - International Journal of …, 2021 - mdpi.com
Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …