Targeting PAI-1 in cardiovascular disease: structural insights into PAI-1 functionality and inhibition

M Sillen, PJ Declerck - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …

From multi-omics approaches to personalized medicine in myocardial infarction

C Zhan, T Tang, E Wu, Y Zhang, M He, R Wu… - Frontiers in …, 2023 - frontiersin.org
Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …

The effect of bedtime versus morning dosing of antihypertensive drugs on the cardiovascular outcomes: a systematic review and meta-analysis of randomized …

M Abuelazm, O Saleh, MM Albarakat… - Journal of …, 2023 - journals.lww.com
Methods: We synthesized randomized controlled studies (RCTs) from the Web of Science,
SCOPUS, EMBASE, PubMed, and CENTRAL until 13 October 2022. The risk ratio (RR) for …

Association between plasminogen activator inhibitor-1 gene polymorphisms and susceptibility to Parkinson's disease in Chinese patients

Q Xu, Q Lai, J Wang, L Zhuang, L Cheng, Y Mo… - Acta Neurologica …, 2022 - Springer
Purpose Parkinson's disease (PD) is a neurodegenerative disease that usually leads to
memory impairment, cognitive decline and dementia. Previous studies have reported that …

[PDF][PDF] Полиморфизм гена SERPINE-1 у пациентов с сердечно-сосудистыми заболеваниями

АФ Усманова, СД Маянская… - Казанский …, 2024 - kazanmedjournal.ru
АННОТАЦИЯ В настоящее время вопросам рецидивирующего течения сердечно-
сосудистых заболеваний придают большое значение. На сегодняшний день идёт …

SERPINE-1 gene polymorphism in patients with cardiovascular diseases

AF Usmanova, SD Mayanskaya… - Kazan medical …, 2024 - kazanmedjournal.ru
Currently, the issues of recurrent course of cardiovascular diseases are given great
importance. Today, there is a search for more and more new factors and causes, including …

[PDF][PDF] Structural analysis of antibody-based and small molecule profibrinolytics

M SILLEN - 2021 - lirias.kuleuven.be
STRUCTURAL ANALYSIS OF ANTIBODY-BASED AND SMALL MOLECULE
PROFIBRINOLYTICS Page 1 KU Leuven Biomedical Sciences Group Department of …

[PDF][PDF] Полиморфные варианты генов PIK3CA, CDKN2B-AS1 и AGTR1 ассоциированы с возрастом дебюта инфаркта миокарда

АР Сидько, ГЖ Осьмак, БВ Титов… - Кардиологический …, 2021 - cardioweb.ru
РЕЗЮМЕ Ранее мы показали возможность возраст-зависимого подхода к оценке риска
развития инфаркта миокарда (ИМ), основанного на анализе носительства аллельных …