This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic
neurotransmission, its activity, and how its inhibition can be pharmacologically useful for …

The translational capacity of data generated in preclinical toxicological studies is contingent
upon several factors, including the appropriateness of the animal model. The primary …

Organophosphates (OPs) are cholinesterase inhibitors that lead to a characteristic
toxidrome of hypersecretion, miosis, dyspnea, respiratory insufficiency, convulsions and …

The use of nerve agents as warfare and in terrorist acts has drawn much attention from the
governments and societies. Such toxic organophosphorus compounds are listed in …

Potent cholinesterase inhibitors such as sarin, induce an array of harmful effects including
hypersecretion, convulsions and ultimately death. Surviving subjects demonstrate damage …

The terroristic availability of highly toxic nerve agents (NAs) highlights the necessity for a
deep understanding of their toxicities and effective medical treatments. A liquid …

In vivo antidotal efficacy of new bis-quaternary 2-(hydroxyimino)-N-(pyridin-3yl) acetamide
derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and …

One hundred years ago, in August of 1914, during the first month of World War I, a group of
French soldiers attacked German troops and, for the first time in declared warfare, used …

JCSP 48 Master of Defence Studies PCEMI 48 Maîtrise en études de la défense Page 1
Chemical, Biological, Radiological, Nuclear, and Explosive National Security Defence …