DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …

Inhibitors of cyclin-dependent kinases (CDKs) 4/6 have emerged as a powerful class of
agents with clinical activity in several malignancies. Targeting the cell cycle represents a …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle
machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

Background Human papillomavirus positive (HPV+) head and neck squamous cell
carcinoma (HNSCC) is an emerging disease, representing a distinct clinical and …

The fallopian tube is now generally considered the dominant site of origin for high-grade
serous ovarian carcinoma. However, the molecular pathogenesis of fallopian tube-derived …

Uncontrolled cell division is a defining characteristic of cancer cells. Cyclin-dependent
kinases (Cdks) are critical regulators of cell cycle progression. Deregulated Cdk activities as …

Precise replication of genetic material is essential to maintain genome stability. DNA
replication is a tightly regulated process that ensues faithful copies of DNA molecules to …

Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein
(SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in …

Abstract m6A modification is the most prevalent RNA modification in eukaryotes. As the
critical N6‐methyladenosine (m6A) methyltransferase, the roles of methyltransferase like 3 …