During the past two decades, the field of mammalian myocardial regeneration has grown
dramatically, and with this expanded interest comes increasing claims of experimental …

The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

BACKGROUND: Experiments in mammalian models of cardiac injury suggest that the
cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery …

Mammalian cardiomyocytes undergo major maturational changes in preparation for birth
and postnatal life. Immature cardiomyocytes contribute to cardiac growth via proliferation …

Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

During heart maturation, gap junctions assemble into hemichannels and polarize to the
intercalated disc at cell borders to mediate electrical impulse conduction. However, the …

During the postnatal period in mammals, the cardiac muscle transitions from hyperplasic to
hypertrophic growth, the extracellular matrix (ECM) undergoes remodeling, and the heart …

Terminally differentiated cells are generally thought to have arrived at their final form and
function. Many terminally differentiated cell types are polyploid, ie they have multiple copies …

Multicellular organisms are composed of tissues with diverse cell sizes. Whether a tissue
primarily consists of numerous, small cells as opposed to fewer, large cells can impact tissue …