Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
[HTML][HTML] CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
RJM Franklin, M Simons - Neuron, 2022 - cell.com
Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …
saltatory conduction and function and sustains axon health. Its declining efficiency with …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia
Y Dong, C D'Mello, W Pinsky, BM Lozinski… - Nature …, 2021 - nature.com
Neurodegeneration occurring in multiple sclerosis (MS) contributes to the progression of
disability. It is therefore important to identify and neutralize the mechanisms that promote …
disability. It is therefore important to identify and neutralize the mechanisms that promote …
The diversity and disparity of the glial scar
Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …
such response, the glial scar, is a structural formation of reactive glia around an area of …
Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair
Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
JD Crapser, MA Arreola, KI Tsourmas… - Cellular & molecular …, 2021 - nature.com
Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
Pathophysiology of the brain extracellular matrix: a new target for remyelination
LW Lau, R Cua, MB Keough… - Nature Reviews …, 2013 - nature.com
The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …
Remyelination therapies: a new direction and challenge in multiple sclerosis
Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …
The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis
S Ghorbani, VW Yong - Brain, 2021 - academic.oup.com
Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …