Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Neurodegeneration occurring in multiple sclerosis (MS) contributes to the progression of
disability. It is therefore important to identify and neutralize the mechanisms that promote …

Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …

Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of
axons allows rapid saltatory conduction of nerve impulses and contributes to axonal …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …