The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Organoids are biomimetic tissue models comprising multiple cell types and cell states. Post-
translational modification (PTM) signaling networks control cellular phenotypes and are …

Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we
describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a …

In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance,
chromatin accessibility and the transcriptome in single cells), enabling interrogation of …

Advances in multi-omics have led to an explosion of multimodal datasets to address
questions from basic biology to translation. While these data provide novel opportunities for …

Single-cell RNA-seq and single-cell assay for transposase-accessible chromatin (ATAC-
seq) technologies are used extensively to create cell type atlases for a wide range of …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

Droplet microfluidic technology has revolutionized biomolecular analytical research, as it
has the capability to reserve the genotype-to-phenotype linkage and assist for revealing the …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Mammalian cells adapt their functional state in response to external signals in form of
ligands that bind receptors on the cell-surface. Mechanistically, this involves signal …